Publications

I started my career studying mechanical engineering. From the fundamentals, I began to focus more on design, calculation, and materials. Later on, I discovered the beauty of biomedical engineering and moved into, tissue mechanics, computational biomechanics, and human body simulation.

Over the years, without acknowledging, my formal education, my professional experience, and my scientific work have led me to the emerging field of in silico. In silico means a test performed on the computer in the context of biomedical products, like drugs, and medical devices. This field is a convergence between mathematics, engineering, computer science, biology, and medicine.

Nowadays, I dedicate most of my time to applying in silico methods in the medical device industry. The keywords that summarize my research career are:

  • Medical Devices
  • Human Body Simulation
  • Patient Digital Twin
  • In Silico evidence
  • Biomedical engineering
  • Computational Modeling and Simulation
  • Tissue Biomechanics

Below, I list my scientific contributions over the years. You can also see my citation metrics on my google scholar profile.

Featured publications

E. Morales-Orcajo, A. Stenti, 2023. “Foot digital twin and in silico clinical applications.Digital Human Modeling and Medicine: The Digital Twin. Academic Press, p. 331-359.

R. Trostorf, E. Morales-Orcajo, A. Pötzke, T. Siebert, M. Böl, 2022. “A pilot study on active and passive ex vivo characterisation of the urinary bladder and its impact on three-dimensional modelling.Journal of the Mechanical Behavior of Biomedical Materials, 133 105347. [PDF ]

A. Stenti, E. Morales-Orcajo, T. Leemrijse, P.-A. Deleu, B. Ferré, 2020. “Foot & Ankle Orthopaedics: Towards the use of In Silico Clinical Trials in Prosthesis Placement Criteria.Conference Proceedings NAFEMS France. [PDF ]

M. Bauer, E. Morales-Orcajo, L. Klemm, R. Seydewitz, V. Fiebach, T. Siebert, M. Böl, 2020. “Biomechanical and microstructural characterisation of the porcine stomach wall: Location- and layer-dependent investigations.Acta Biomaterialia 102 83–99. [PDF ]

E. Morales-Orcajo, J. Bayod, E. Barbosa de Las Casas, 2016. “Computational Foot Modeling: Scope and Applications.Archives of Computational Methods in Engineering (2016) 23:389–416. [PDF ]

All my publications

  1. Toward Good Simulation Practice“2024, Springer.
  2. In Silico Alternative Methods Cluster Summary Report” 2024, Reagan-Udall Foundation for the FDA. [PDF ]
  3. Good Simulation Practices/Computational Modeling & Simulation Cluster Summary Report” 2023, Reagan-Udall Foundation for the FDA. [PDF ]
  4. L. Jäger, E. Morales-Orcajo, A. Gager, A. Bader, A. Dillinger, A. Blutke, 2023. “Pre-Clinical Assessment of Tissue Effects by Gastrointestinal Endoscope Tip Temperature.Current Therapeutic Research, 98: 100693. [PDF ]
  5. E. Morales-Orcajo, A. Stenti, 2023. “Foot digital twin and in silico clinical applications.Digital Human Modeling and Medicine: The Digital Twin. Academic Press, p. 331-359.
  6. R. Trostorf, E. Morales-Orcajo, A. Pötzke, T. Siebert, M. Böl, 2022. “A pilot study on active and passive ex vivo characterisation of the urinary bladder and its impact on three-dimensional modelling.Journal of the Mechanical Behavior of Biomedical Materials, 133 105347. [PDF ]
  7. M. Böl, S. Kohn, K. Leichsenring, E. Morales-Orcajo, A. E. Ehret, 2022. “On multiscale tension-compression asymmetry in skeletal muscle.Acta Biomaterialia 144 210-220. [PDF ]
  8. R. Kuravi, K. Leichsenring, R. Trostorf, E. Morales-Orcajo, M. Böl, A. E. Ehret, 2021. “Predicting muscle tissue response from calibrated component models and histology-based finite element models.Journal of the Mechanical Behavior of Biomedical Materials 117 104375. [PDF ]
  9. R. Trostorf, E. Morales-Orcajo, T. Siebert, M. Böl, 2021. “Location- and layer-dependent biomechanical and microstructural characterisation of the porcine urinary bladder wall.Journal of the Mechanical Behavior of Biomedical Materials 115 104275. [PDF ]
  10. A. Stenti, E. Morales-Orcajo, T. Leemrijse, P.-A. Deleu, B. Ferré, 2020. “Foot & Ankle Orthopaedics: Towards the use of In Silico Clinical Trials in Prosthesis Placement Criteria.Conference Proceedings NAFEMS France. [PDF ]
  11. A. Stenti, E. Morales-Orcajo, F. Giuliani, R. Desmet, T. Leemrijse, P.-A. Deleu, B. Ferré, E. Lété, 2020. “Foot & Ankle Orthopaedics: Towards In Silico Clinical Trials in Prosthesis Wear Estimation.Proceedings Virtual Physiological Human. [PDF ]
  12. E. Morales-Orcajo, A. Stenti, A-X. Fan, A. Balabanis, S-Y. Ye, T. Leemrijse, P.-A. Deleu, B. Ferré, E. Lété, 2020. “3DOrthoTwin: highly automatic generation of subject-specific foot finite element models.Proceedings of the SIMBIO-M conference. [PDF ]
  13. M. Bauer, E. Morales-Orcajo, L. Klemm, R. Seydewitz, V. Fiebach, T. Siebert, M. Böl, 2020. “Biomechanical and microstructural characterisation of the porcine stomach wall: Location- and layer-dependent investigations.Acta Biomaterialia 102 83–99. [PDF ]
  14. L. Klemm, R. Seydewitz, E. Morales-Orcajo, M. Böl, 2019. “On the electro-chemo-mechanical modelling of stomach smooth muscle contraction.Proceedings in Applied Mathematics & Mechanics. [PDF ]
  15. M. Borsdorf,  A. Tomalka,  N. Stutzig, E. Morales-Orcajo, M. Böl,  T. Siebert, 2019. “Locational and directional dependencies of smooth muscle properties in pig urinary bladder.Frontiers in Physiology 10:63, 1-12. [PDF ]
  16. E. Morales-Orcajo, T. Siebert, M. Böl, 2018. “Location-dependent correlation between tissue structure and the mechanical behaviour of the urinary bladderActa Biomaterialia 75 263–278 [PDF ]
  17. E. Morales-Orcajo, R. B. de Bengoa Vallejo, M. Losa Iglesias, J. Bayod,  E. B. de Las Casas, 2018. “Foot internal stress distribution during impact in barefoot running as function of the strike pattern.Computer Methods in Biomechanics and Biomedical Engineering 21:7, 471-478 [PDF ]
  18. R. Seydewitz, E. Morales-Orcajo, M. Böl, 2017. “Modelling the contraction properties of smooth muscle cells in bladder tissue.Proceedings in Applied Mathematics & Mechanics 17, 223–224 [PDF ]
  19. E. Morales-Orcajo, T. R. Souza, J. Bayod, E. Barbosa de Las Casas, 2017. “Non-linear finite element model to assess the effect of tendon forces on the foot-ankle complex.Medical Engineering and Physics 49 71–78 [PDF ]
  20. E. Morales-Orcajo, R. Becerro de Bengoa Vallejo, M. Losa Iglesias, J. Bayod, 2016. “Structural and material properties of human foot tendons.Clinical Biomechanics 37 1–6 [PDF ]
  21. E. Morales-Orcajo, J. Bayod, E. Barbosa de Las Casas, 2016. “Computational Foot Modeling: Scope and Applications.Archives of Computational Methods in Engineering (2016) 23:389–416 [PDF ]
  22. E. Morales-Orcajo, J. Bayod,  R. Becerro de Bengoa Vallejo, M. Losa Iglesias, M. Doblare, 2015. “Influence of first proximal phalanx geometry on hallux valgus deformity: a finite element analysis.Medical & Biological Engineering & Computing 53:645–653 [PDF ]
  23. E. Morales-Orcajo, 2015. “Computational foot modeling for clinical assessment” University of Zaragoza (2015) [PDF ] [UZ repository] [UFMG repository]

I also review original research studies on biomedical engineering, in-silico trials, and experimental biomechanics. You can see my review statistics on my profile in web of science.

This work keeps me up-to-date on the latest scientific advances before the results are publicly available. I evaluate the quality, significance, and originality of preprints for the journals:

Journal of Medical Devices
Artificial Organs
Clinical Biomechanics cover
Clinical Biomechanics
Journal of Applied Mathematics and Mechanics
Journal of the Brazilian Society of Mechanical Sciences and Engineering